Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NMT2 | O60551 | 2/20 | 0.34 |
| ▸ | NMT1 | P30419 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5542969 | 0.81 | HTR1B (0.53) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28857172 | 0.79 | IDO1 (0.38) | — | |
| SCHEMBL6238419 | 0.78 | JAK2 (0.33) | GAAALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL27539916 | 0.75 | HTR1B (0.44) | KDM4EMEN1KMT2AHTR1BCYP2D6 | |
| SCHEMBL7023418 | 0.75 | HTR1B (0.50) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL29068363 | 0.75 | CA12 (0.50) | CYP2D6 | |
| SCHEMBL14176499 | 0.74 | GAA (0.55) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL126227 | 0.74 | ALDH1A1 (0.34) | GAAALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL7723079 | 0.74 | DUT (0.36) | — | |
| SCHEMBL7329092 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395528-B1 | 4-Phenylmethyl-1H-indole derivatives, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1995-07-05 | — | — | EP | disclosed |
| EP-0395528-A2 | 4-Phenylmethyl-1H-indole derivatives, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-10-31 | — | — | EP | disclosed |