SCHEMBL7329124

SCHEMBL7329124

CC(C)(C)OC(=O)N(N)CC1CCCCC1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.43
EPHX1 P07099 2/20 0.37
CTSK P43235 2/20 0.36
CTSS P25774 1/20 0.36
GAA P10253 1/20 0.35
HTR2C P28335 2/20 0.34
SLC6A4 P31645 2/20 0.34
BACE1 P56817 2/20 0.33
CTSD P07339 1/20 0.33
CNR2 P34972 1/20 0.33
HPGD P15428 1/20 0.33
GRM2 Q14416 1/20 0.33
GRM3 Q14832 1/20 0.33
CHRM2 P08172 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1782688 0.91 ALOX5 (0.38) ALOX5CTSKCTSSCNR2CHRM2
SCHEMBL6531991 0.85 EPHX1 (0.36) ALOX5EPHX1CTSKCTSSGAA
SCHEMBL7332327 0.84 CTSD (0.36) CTSSGAACTSDCNR2
SCHEMBL10324374 0.83 EPHX1 (0.34) ALOX5EPHX1CTSKCTSSGAA
SCHEMBL9306400 0.83 ALOX5 (0.55) ALOX5EPHX1CTSKCTSSGAA
SCHEMBL3301278 0.82 CPN1 (0.37) EPHX1SLC6A4BACE1
SCHEMBL8911411 0.81 HTR2C (0.42) ALOX5EPHX1CTSKCTSSGAA
SCHEMBL21574018 0.81 HTR2C (0.42) ALOX5EPHX1CTSKCTSSGAA
SCHEMBL4971636 0.81 EPHX1 (0.35) ALOX5EPHX1CTSKCTSSGAA
SCHEMBL7186502 0.81 ALOX5 (0.41) ALOX5EPHX1CTSKCTSSGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5990135-A FOR TREATING A RETROVIRAL INFECTION SUCH AS HIV INFECTION; FOR EXAMPLE 5S-N-((2-PYRIDINYL)METHOXYCARBONYL)VALINYLAMINO-2-((N-3 -PYRIDINYL)METHOXYCARBONYL)AMINO-4S-HYDROXY-1,6-DIPHENYL-2-AZAHEXANE AND OTHER COMPOUNDS OF GIVEN FORMULA ABBOTT LABORATORIES (US) 1999-11-23 US disclosed
US-5631376-A PEPTIDE DERIVATIVES FOR TREATMENT OF AIDS ABBOTT LABORATORIES (US) 1997-05-20 US disclosed
US-5621109-A OXAZOLE/THIAZOLE DERIVATIVES OF HYDROXYMETHYL HYDRAZONES; SIDE EFFECT REDUCTION ABBOTT LABORATORIES (US) 1997-04-15 US disclosed
US-5461067-A For HIV infections ABBOTT LABORATORIES (US) 1995-10-24 US disclosed
WO-1994019332-A1 RETROVIRAL PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 1994-09-01 WO disclosed