Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.58 |
| ▸ | CTSD | P07339 | 4/20 | 0.57 |
| ▸ | REN | P00797 | 5/20 | 0.56 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329749 | 0.86 | CTSD (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7322916 | 0.86 | CTSD (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7332313 | 0.85 | REN (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7322717 | 0.81 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7323581 | 0.80 | TRPM8 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7329306 | 0.80 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7330477 | 0.80 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7322778 | 0.78 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28961339 | 0.78 | CTSD (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11661865 | 0.78 | CTSD (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990000399-A1 | RETROVIRAL PROTEASE BINDING PEPTIDES | SMITHKLINE BECKMAN CORPORATION (US) | 1990-01-25 | — | — | WO | disclosed |
| EP-0352000-A2 | Retroviral protease binding peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |