Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.48 |
| ▸ | CTSD | P07339 | 2/20 | 0.45 |
| ▸ | CTSE | P14091 | 2/20 | 0.45 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.43 |
| ▸ | PGC | P20142 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329922 | 0.91 | ALDH1A1 (0.40) | RENCTSDCTSE | |
| SCHEMBL7333169 | 0.90 | REN (0.48) | RENCTSDCTSE | |
| SCHEMBL7332589 | 0.88 | REN (0.39) | RENCTSDCTSE | |
| SCHEMBL7337353 | 0.88 | REN (0.38) | RENCTSDCTSE | |
| SCHEMBL7336873 | 0.85 | REN (0.40) | REN | |
| SCHEMBL7335450 | 0.81 | REN (0.58) | RENCTSDCTSE | |
| SCHEMBL7331287 | 0.77 | REN (0.63) | RENCTSDCTSEPGA5PGC | |
| SCHEMBL9680246 | 0.74 | REN (0.51) | RENCTSDCTSEPGA5PGC | |
| SCHEMBL8955003 | 0.73 | REN (0.66) | RENCTSDCTSE | |
| SCHEMBL7340387 | 0.73 | REN (0.53) | RENCTSDCTSEPGA5PGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |