Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.66 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | CTSE | P14091 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9322207 | 0.92 | REN (0.67) | RENCTSDCTSE | |
| Hydrochloric Acid SCHEMBL8955332 | 0.91 | REN (0.66) | RENCTSDCTSE | |
| SCHEMBL7335450 | 0.82 | REN (0.58) | RENCTSDCTSE | |
| SCHEMBL9458635 | 0.81 | REN (1.00) | RENCTSDCTSE | |
| SCHEMBL7317104 | 0.79 | MEN1 (0.61) | RENCTSDCTSEMEN1ALDH1A1 | |
| SCHEMBL7385524 | 0.79 | MEN1 (0.61) | RENCTSDCTSEMEN1ALDH1A1 | |
| SCHEMBL8955175 | 0.76 | CTSC (0.46) | REN | |
| SCHEMBL8955190 | 0.76 | CTSC (0.46) | REN | |
| SCHEMBL9556735 | 0.76 | REN (0.50) | RENCTSDCTSE | |
| SCHEMBL7331287 | 0.75 | REN (0.63) | RENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581899-A4 | IMPROVED PROCESS FOR THE PREPARATION OF 1S-(1R*, 2S*, 3R*))-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N- (1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL)-L-ALANINAMIDE | WARNER LAMBERT CO (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1994011336-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF SUBSTITUTED 1,2,3-AMINODIOLS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |
| EP-0581899-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N- (1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5268483-A | Process for the preparation of an L-alanine compound | WARNER-LAMBERT COMPANY (US) | 1993-12-07 | — | — | US | disclosed |
| US-5220031-A | Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1992018486-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N-[(1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5089616-A | Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |