Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31179785 | 0.88 | CES2 (0.44) | LCKFYNCYP1A2AKR1C3MAPT | |
| SCHEMBL6342428 | 0.86 | MEN1 (0.49) | LCKFYNCXCR2HSD11B1AURKA | |
| SCHEMBL14562524 | 0.82 | PPARG (0.56) | KMT2APPARGAKR1C3 | |
| SCHEMBL732952 | 0.82 | NOTUM (0.45) | CXCR2CA12CA1CA2CA7 | |
| SCHEMBL6339765 | 0.81 | TTR (0.41) | MEN1KMT2AWDR5PPARGAKR1C3 | |
| SCHEMBL200874 | 0.81 | HSD11B1 (0.46) | CXCR2HSD11B1CXCR1MEN1KMT2A | |
| SCHEMBL926505 | 0.80 | CA2 (0.41) | CXCR2HSD11B1CXCR1CA1CA2 | |
| SCHEMBL840762 | 0.80 | KMT2A (0.50) | CXCR2CXCR1MEN1KMT2ACA12 | |
| SCHEMBL4612184 | 0.79 | LCK (0.54) | LCKFYNCYP1A2MEN1KMT2A | |
| SCHEMBL4391166 | 0.78 | NOTUM (0.45) | CXCR2HSD11B1CXCR1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| US-6949674-B2 | Aromatic carboxylic acids, acid halides thereof and processes for preparing both | SUMITOMO BAKELITE COMPANY, LTD. (JP) | 2005-09-27 | — | — | US | disclosed |
| US-20040068139-A1 | Aromatic carboxylic acids, acid halides thereof and processes for preparing both | SUMITOMO BAKELITE COMPANY, LTD. (JP) | 2004-04-08 | — | — | US | disclosed |
| US-20040002572-A1 | Material for an insulating film, coating varnish for an insulating film, and insulating film and semiconductor device using the same | SUMITOMO BAKELITE COMPANY, LTD. (JP) | 2004-01-01 | — | — | US | disclosed |
| EP-1346975-A1 | AROMATIC CARBOXYLIC ACIDS, ACID HALIDES THEREOF AND PROCESSES FOR PREPARING BOTH | SUMITOMO BAKELITE CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | LCK 3891/4885FYN 3873/4885CYP1A2 98/4885 |
| US-20040068139-A1 | Aromatic carboxylic acids, acid halides thereof and processes for preparing both | CCR1, CCRL2, CCR6 | LCK 1649/4885FYN 3773/4885CYP1A2 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.