Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337972 | 0.85 | GABRA1 (0.38) | HSD17B10HPGD | |
| SCHEMBL29729255 | 0.72 | CYP2C9 (0.51) | HSD17B10CYP2C9HPGDALDH1A1KDM4E | |
| SCHEMBL9773340 | 0.65 | PTPN2 (0.46) | HSD17B10TSHRRECQLHPGDALDH1A1 | |
| SCHEMBL6474233 | 0.65 | HPGD (0.63) | CYP2C9TSHRHPGDALDH1A1KDM4E | |
| SCHEMBL4827189 | 0.65 | ALDH1A1 (0.69) | TSHRRECQLHPGDALDH1A1MEN1 | |
| SCHEMBL6479981 | 0.65 | MAPT (0.62) | HSD17B10RECQLHPGDALDH1A1KDM4E | |
| SCHEMBL9657485 | 0.64 | GABRA5 (0.54) | HSD17B10TSHRHPGDALDH1A1KDM4E | |
| SCHEMBL10720608 | 0.64 | TSHR (0.69) | TSHRRECQLHPGDALDH1A1KDM4E | |
| SCHEMBL3901397 | 0.64 | IDO1 (0.54) | HSD17B10TSHRRECQLHPGDALDH1A1 | |
| SCHEMBL16051336 | 0.64 | ALDH1A1 (0.67) | TSHRRECQLHPGDALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729469-A1 | IMIDAZO [1,5-a]QUINOLINES FOR TREATMENT OF ANXIETY AND SLEEP DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014020-A1 | IMIDAZO[1,5-a]QUINOLINES FOR TREATMENT OF ANXIETY AND SLEEP DISORDERS | THE UPJOHN COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |