Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329520 | 0.85 | HSD17B10 (0.43) | HPGDHSD17B10 | |
| SCHEMBL7332980 | 0.78 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA5HPGD | |
| SCHEMBL7291196 | 0.71 | PTPN2 (0.41) | GABRA1GABRG2GABRB3GABRA5HPGD | |
| SCHEMBL9599814 | 0.69 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7335649 | 0.67 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7335647 | 0.67 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9075553 | 0.67 | — | — | |
| SCHEMBL9606957 | 0.67 | GABRA5 (0.46) | GABRA1GABRG2GABRB3GABRA5HPGD | |
| SCHEMBL9077632 | 0.67 | — | — | |
| SCHEMBL9078291 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935970-A | Use of imidazo 1,5-a!quinolones as neuroprotective agents | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-10 | — | — | US | claimed |
| US-RE35840-E | Imidazo 1,5-a!quinolines for treatment of anxiety and sleep disorders | PHARMACIA & UPJOHN COMPANY (US) | 1998-07-07 | — | — | US | claimed |
| US-5594140-A | Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | claimed |
| WO-1997000074-A1 | USE OF IMIDAZO[1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-03 | — | — | WO | claimed |
| EP-0729469-A1 | IMIDAZO [1,5-a]QUINOLINES FOR TREATMENT OF ANXIETY AND SLEEP DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-09-04 | — | — | EP | claimed |
| WO-1995014020-A1 | IMIDAZO[1,5-a]QUINOLINES FOR TREATMENT OF ANXIETY AND SLEEP DISORDERS | THE UPJOHN COMPANY (US) | 1995-05-26 | — | — | WO | claimed |