Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337599 | 0.83 | TNKS (0.39) | ALDH1A1KDM4EPARP1TNKSTNKS2 | |
| SCHEMBL7328415 | 0.82 | MAPT (0.38) | ALDH1A1KDM4EGAAMAPTPARP1 | |
| SCHEMBL7331334 | 0.74 | BRD4 (0.36) | ALDH1A1KDM4EGAAMAPTTSHR | |
| SCHEMBL7338197 | 0.73 | CTSV (0.35) | ALDH1A1KDM4EGAAMAPTPARP1 | |
| SCHEMBL7329545 | 0.69 | TNKS (0.41) | ALDH1A1KDM4EGAATHRBMAPT | |
| SCHEMBL16664837 | 0.67 | ALDH1A1 (0.51) | ALDH1A1KDM4EGAATHRBMAPT | |
| SCHEMBL19501571 | 0.59 | MAPT (0.41) | ALDH1A1KDM4EMAPTHPGDCYP2C9 | |
| SCHEMBL3918612 | 0.58 | ALDH1A1 (0.51) | ALDH1A1KDM4EGAATHRBMAPT | |
| SCHEMBL7729347 | 0.58 | KDM4E (0.52) | ALDH1A1KDM4EGAATHRBMAPT | |
| SCHEMBL7336678 | 0.57 | TNKS (0.74) | ALDH1A1KDM4EGAAMAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |