Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329537 | 0.83 | ALDH1A1 (0.37) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL7328415 | 0.79 | MAPT (0.38) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL7337601 | 0.72 | TNKS (0.43) | TNKSPARP1COMTTNKS2PARP2 | |
| SCHEMBL7331334 | 0.71 | BRD4 (0.36) | PARP1TDP2KDM4EALDH1A1 | |
| SCHEMBL7338197 | 0.70 | CTSV (0.35) | PARP1KDM4EALDH1A1 | |
| SCHEMBL7397534 | 0.69 | TNKS (0.41) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL15693150 | 0.68 | TNKS (0.52) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL15614396 | 0.62 | ERCC1 (0.67) | TNKSPARP1COMTTNKS2 | |
| SCHEMBL15287390 | 0.62 | TNKS (0.71) | TNKSPARP1TNKS2PARP2 | |
| SCHEMBL15775516 | 0.61 | TNKS (0.56) | TNKSPARP1TNKS2ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |