SCHEMBL7329581

SCHEMBL7329581

COC(=O)C(C)CN1CC(=O)N(C)c2ccc(CCCCC(C)NC(=O)OC(C)(C)C)cc2C1=O

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33
GABRB2 P47870 1/20 0.33
GABRA6 Q16445 1/20 0.33
SCN9A Q15858 7/20 0.32
PRMT5 O14744 1/20 0.32
WDR77 Q9BQA1 1/20 0.32
LIPG Q9Y5X9 2/20 0.31
ITGB3 P05106 1/20 0.31
ITGA2B P08514 1/20 0.31
CA2 P00918 2/20 0.30
CA1 P00915 1/20 0.30
NFKB1 P19838 1/20 0.30
NFKB2 Q00653 1/20 0.30
RELA Q04206 1/20 0.30
CYP11B1 P15538 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7323774 0.83 ITGB3 (0.40) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL7325330 0.76 KLK7 (0.41) ITGB3ITGA2B
SCHEMBL7329048 0.74 CASP3 (0.41) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL7323919 0.73 ITGB3 (0.34) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL7330995 0.71 ITGB3 (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
Trifluoroacetic Acid SCHEMBL7323917 0.70 ITGB3 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL7330617 0.70 SIGMAR1 (0.42)
SCHEMBL7331888 0.67 SCN9A (0.35) GABRA1GABRG2GABRB3GABRA5GABRA3
Trifluoroacetic Acid SCHEMBL8837001 0.67 ITGB3 (0.46) ITGB3ITGA2B
SCHEMBL27962221 0.65 CTSK (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674863-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5674865-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5663166-A ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING GENENTECH, INC. (US) 1997-09-02 US disclosed
US-5565449-A PLATELET AGGREGATION INHIBITORS GENENTECH, INC. (US) 1996-10-15 US disclosed
EP-0610334-B1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR GENENTECH INC (US) 1996-01-24 EP disclosed
EP-0610334-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. GENENTECH INC (US) 1994-08-17 EP disclosed
WO-1993008174-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR GENENTECH, INC. (US) 1993-04-29 WO disclosed