Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 3/20 | 0.38 |
| ▸ | EDNRA | P25101 | 3/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328086 | 0.87 | ALDH1A1 (0.40) | ALDH1A1GFERSLC6A4HTR2AKCNH2 | |
| SCHEMBL8323583 | 0.85 | ALDH1A1 (0.38) | ALDH1A1GFERSLC6A4HTR2AKCNH2 | |
| SCHEMBL7298739 | 0.84 | CDK1 (0.43) | ALDH1A1GFERSLC6A4HTR2AKCNH2 | |
| SCHEMBL4435549 | 0.79 | EDNRB (0.44) | ALDH1A1SLC6A4HTR2AKCNH2KDM4E | |
| SCHEMBL8323581 | 0.78 | HTR2A (0.40) | ALDH1A1GFERSLC6A4HTR2AKCNH2 | |
| SCHEMBL7330437 | 0.76 | DHPS (0.59) | ALDH1A1DHPSCA12CA1CA2 | |
| SCHEMBL7332509 | 0.76 | RORC (0.38) | ALDH1A1KDM4EGAA | |
| SCHEMBL8328712 | 0.72 | KMT2A (0.37) | ALDH1A1SLC6A4HTR2AKCNH2KDM4E | |
| SCHEMBL7417417 | 0.72 | ALDH1A1 (0.47) | ALDH1A1GFERKDM4EGAA | |
| SCHEMBL858910 | 0.72 | ALDH1A1 (0.50) | ALDH1A1GFERKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |