Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328378 | 0.86 | TNKS (0.38) | KDM4EALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL7329545 | 0.84 | TNKS (0.41) | KDM4EALDH1A1LMNAGLAGAA | |
| SCHEMBL7327732 | 0.84 | TNKS (0.39) | KDM4EALDH1A1GAAHPGDNPC1 | |
| SCHEMBL7331035 | 0.81 | MAPT (0.48) | ALDH1A1LMNAPGRMEN1NPC1 | |
| SCHEMBL7327605 | 0.78 | TNKS (0.53) | KDM4EALDH1A1LMNAGLAGAA | |
| SCHEMBL15287352 | 0.75 | PARP1 (0.53) | BRD4KDM4EALDH1A1LMNAGLA | |
| SCHEMBL7336871 | 0.74 | MAP2K1 (0.44) | KDM4EALDH1A1LMNAGLAGAA | |
| SCHEMBL7330447 | 0.72 | BRD4 (0.41) | BRD4KDM4EALDH1A1LMNAGLA | |
| SCHEMBL7328423 | 0.72 | MAPT (0.42) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL7337908 | 0.71 | SCN10A (0.38) | KDM4EALDH1A1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |