Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328372 | 0.86 | NPC1 (0.35) | KDM4EALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL7329537 | 0.84 | ALDH1A1 (0.37) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL7327728 | 0.84 | TNKS (0.37) | KDM4EALDH1A1GAAHPGDPARP1 | |
| SCHEMBL7331031 | 0.81 | MAPT (0.48) | PGRALDH1A1GAALMNAMEN1 | |
| SCHEMBL7337599 | 0.73 | TNKS (0.39) | KDM4EALDH1A1PARP1 | |
| SCHEMBL7331334 | 0.73 | BRD4 (0.36) | BRD4KDM4EALDH1A1GAAHPGD | |
| SCHEMBL7330451 | 0.72 | BRD4 (0.41) | BRD4PGRKDM4EALDH1A1GAA | |
| SCHEMBL7338197 | 0.72 | CTSV (0.35) | KDM4EALDH1A1GAAGLAMEN1 | |
| SCHEMBL7337898 | 0.72 | TDP2 (0.38) | — | |
| SCHEMBL15287352 | 0.64 | PARP1 (0.53) | BRD4PGRKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |