Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000543 | 0.83 | ALDH1A1 (0.53) | FAAHCNR1CNR2MRGPRX1MEN1 | |
| SCHEMBL17206382 | 0.81 | FAAH (0.51) | FAAHCNR1CNR2MRGPRX1PDE4A | |
| SCHEMBL27854331 | 0.80 | FAAH (0.51) | FAAHCNR1CNR2MRGPRX1PDE4A | |
| SCHEMBL933677 | 0.79 | ALDH1A1 (0.57) | FAAHCNR1CNR2MRGPRX1KMT2A | |
| SCHEMBL11628242 | 0.77 | RIPK1 (0.46) | FAAHCNR1CNR2MRGPRX1PDE4A | |
| SCHEMBL27983423 | 0.77 | FAAH (0.52) | FAAHCNR1CNR2MRGPRX1PDE4A | |
| Hydrochloric Acid SCHEMBL7726218 | 0.76 | HTR2C (0.48) | FAAHCNR1CNR2MRGPRX1PDE4A | |
| SCHEMBL7329125 | 0.76 | FAAH (0.47) | FAAHCNR1CNR2MRGPRX1MEN1 | |
| SCHEMBL1474965 | 0.74 | IRAK4 (0.51) | MEN1KMT2AALDH1A1PARP15PARP10 | |
| SCHEMBL11466965 | 0.74 | PARP15 (0.49) | FAAHCNR1CNR2MRGPRX1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422846-B1 | Aroyl-ureas | WYETH JOHN & BROTHER LTD (GB) | 1994-02-16 | — | — | EP | claimed |
| EP-0422846-A2 | Aroyl-ureas | JOHN WYETH & BROTHER LIMITED (GB) | 1991-04-17 | — | — | EP | claimed |
| US-5436251-A | Treating neuro-psychiatric disorders gastrointenstinal disorders or migranes | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-07-25 | — | — | US | disclosed |
| EP-0422846-B1 | Aroyl-ureas | WYETH JOHN & BROTHER LTD (GB) | 1994-02-16 | — | — | EP | disclosed |
| EP-0422846-A2 | Aroyl-ureas | JOHN WYETH & BROTHER LIMITED (GB) | 1991-04-17 | — | — | EP | disclosed |