Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933677 | 0.88 | ALDH1A1 (0.57) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL27983423 | 0.86 | FAAH (0.52) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL4000543 | 0.86 | ALDH1A1 (0.53) | FAAHCNR1CNR2MRGPRX1PARP15 | |
| SCHEMBL3064765 | 0.81 | FAAH (0.54) | FAAHCNR1CNR2MRGPRX1HTR2C | |
| SCHEMBL29055574 | 0.81 | FAAH (0.57) | FAAHCNR1CNR2PARP15PARP10 | |
| SCHEMBL1388095 | 0.80 | FAAH (0.60) | FAAHCNR1CNR2PARP15PARP10 | |
| SCHEMBL9366238 | 0.80 | FAAH (0.44) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL7330508 | 0.80 | FAAH (0.53) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL11628242 | 0.79 | RIPK1 (0.46) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL238499 | 0.79 | PTGER1 (0.47) | FAAHCNR1CNR2MRGPRX1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471314-B | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction | ROTTAPHARM SPA | 2015-05-13 | — | — | CN | claimed |
| CN-102471314-B | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction | ROTTAPHARM SPA | 2015-05-13 | — | — | CN | disclosed |
| CN-102471314-A | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction | ROTTAPHARM SPA | 2012-05-23 | — | — | CN | disclosed |