Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 3/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14507262 | 0.84 | DRD2 (0.47) | DRD2DRD4DRD3AMY1AMC4R | |
| SCHEMBL6859787 | 0.73 | AMY1A (0.49) | DRD2DRD4DRD3AMY1AGRK6 | |
| SCHEMBL12714762 | 0.70 | ALDH1A1 (0.50) | ALDH1A1MAPTPOLBMEN1MAPK1 | |
| SCHEMBL12284103 | 0.70 | FFAR1 (0.46) | AMY1AGRK6 | |
| SCHEMBL14125145 | 0.70 | GAA (0.56) | AMY1AGRK6MGAMGAASI | |
| SCHEMBL18512282 | 0.67 | AMY1A (0.48) | DRD2DRD4DRD3AMY1AGRK6 | |
| SCHEMBL14266638 | 0.67 | CBFB (0.58) | LMNAPOLBSMN1; SMN2 | |
| SCHEMBL28895392 | 0.66 | GAA (0.53) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL10206881 | 0.66 | AMY1A (0.56) | AMY1AGRK6MAPTMEN1KMT2A | |
| SCHEMBL31277617 | 0.66 | POLB (0.49) | GRK6MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681956-A | USEFUL IN DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA AND DEPRESSION AS WELL AS PARKINSONISM | NEUROGEN CORPORATION (US) | 1997-10-28 | — | — | US | disclosed |
| EP-0783494-A1 | CERTAIN AMINOMETHYL PHENYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5646279-A | USEFUL IN THE DIAGNOSIS AND TREATMENT OF AFFECTIVE DISORDERS, MOVEMENT DISORDERS AND SIDE EFFECTS ASSOCIATED WITH NEUROLEPTIC AGENTS | NEUROGEN CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5646280-A | FOR TREATING SCHIZOPHRENIA, DEPRESSION, PARKINSON*S DISEASE AND THE SIDE EFFECTS OF NEUROLEPTIC AGENTS | NEUROGEN CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5633376-A | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands | NEUROGEN CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| WO-1996010018-A1 | CERTAIN AMINOMETHYL PHENYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1996-04-04 | — | — | WO | disclosed |
| US-5428164-A | Useful for treating and diagnosis of schizophrenia and depression as well as parkinson's disease | NEUROGEN CORPORATION (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0640075-A1 | CERTAIN AMINOMETHYL PHENYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5159083-A | Treatment of schizophrenia, depression, parkinson's disease; side effect reduction | NEUROGEN CORPORATION (US) | 1992-10-27 | — | — | US | disclosed |
| WO-1992012134-A2 | CERTAIN AMINOMETHYL PHENYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1992-07-23 | — | — | WO | disclosed |