Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | RHOA | P61586 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334663 | 0.83 | TRPV1 (0.30) | LMNAHTTALDH1A1 | |
| SCHEMBL7321679 | 0.80 | TLR3 (0.42) | TLR3AKR1B1SIRT2HSP90AA1HIF1A | |
| SCHEMBL7325003 | 0.80 | ABCC9 (0.40) | SIRT2LMNAABCC9 | |
| SCHEMBL7321412 | 0.80 | ABCC9 (0.39) | TLR3AKR1B1HSP90AA1HIF1AMAPT | |
| SCHEMBL7334818 | 0.79 | AKR1B1 (0.35) | TLR3AKR1B1SIRT2HSP90AA1HIF1A | |
| SCHEMBL7331033 | 0.79 | ABCC9 (0.35) | TLR3AKR1B1HSP90AA1HIF1AMAPT | |
| SCHEMBL8084928 | 0.74 | AKR1B1 (0.37) | AKR1B1HSP90AA1HIF1AALDH1A1 | |
| SCHEMBL8184295 | 0.73 | TLR3 (0.36) | TLR3AKR1B1SIRT2NPC1RAB9A | |
| SCHEMBL9689179 | 0.71 | TLR3 (0.45) | TLR3AKR1B1SIRT2HSP90AA1HIF1A | |
| SCHEMBL9689181 | 0.71 | TLR3 (0.45) | TLR3AKR1B1SIRT2HSP90AA1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |