Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325003 | 0.84 | ABCC9 (0.40) | LMNA | |
| SCHEMBL7330893 | 0.83 | TLR3 (0.40) | ALDH1A1LMNAHTT | |
| SCHEMBL7326497 | 0.79 | LMNA (0.33) | TRPV1ALDH1A1LMNAHTT | |
| SCHEMBL7330531 | 0.78 | ABCC9 (0.38) | — | |
| SCHEMBL7332017 | 0.77 | ALDH1A1 (0.30) | ALDH1A1LMNAHTT | |
| SCHEMBL7331727 | 0.77 | ABCC9 (0.30) | — | |
| SCHEMBL12315587 | 0.72 | BACE1 (0.32) | TRPV1ALDH1A1LMNAHTT | |
| SCHEMBL28768382 | 0.72 | TRPV1 (0.36) | TRPV1IDO1 | |
| SCHEMBL9141913 | 0.70 | TLR3 (0.43) | TRPV1ALDH1A1LMNA | |
| SCHEMBL2184227 | 0.69 | AKR1B1 (0.40) | TRPV1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |