Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334818 | 0.82 | AKR1B1 (0.35) | AKR1B1HIF1AHSP90AA1ALDH1A1 | |
| SCHEMBL7331033 | 0.76 | ABCC9 (0.35) | AKR1B1HIF1AHSP90AA1ALDH1A1 | |
| SCHEMBL7321412 | 0.75 | ABCC9 (0.39) | AKR1B1HIF1AHSP90AA1ALDH1A1 | |
| SCHEMBL7330893 | 0.74 | TLR3 (0.40) | AKR1B1HIF1AHSP90AA1ALDH1A1 | |
| SCHEMBL7326918 | 0.72 | AKR1B1 (0.35) | AKR1B1ALDH1A1 | |
| SCHEMBL9377381 | 0.65 | KDM4E (0.36) | AKR1B1ALDH1A1 | |
| SCHEMBL7332017 | 0.65 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL7323754 | 0.65 | ABCC9 (0.39) | AKR1B1HIF1AHSP90AA1ALDH1A1 | |
| SCHEMBL7332446 | 0.64 | MAPT (0.33) | AKR1B1HIF1AALDH1A1 | |
| SCHEMBL8085025 | 0.64 | AKR1B1 (0.33) | AKR1B1HIF1AHSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0340718-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1994-07-20 | — | — | EP | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |