Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | FCER2 | P06734 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.47 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.45 |
| ▸ | CTRL | P40313 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.44 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.44 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.44 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329490 | 0.89 | REN (0.54) | RENMMP1FCER2MMEERAP2 | |
| SCHEMBL7336427 | 0.89 | FCER2 (0.49) | RENMMP1FCER2MMEERAP2 | |
| SCHEMBL7339533 | 0.86 | LTA4H (0.48) | RENMME | |
| SCHEMBL7328611 | 0.86 | REN (0.53) | RENMMP1FCER2MMEERAP2 | |
| SCHEMBL7336719 | 0.86 | FCER2 (0.47) | RENMMP1FCER2MMEERAP2 | |
| SCHEMBL7331287 | 0.83 | REN (0.63) | REN | |
| SCHEMBL7334299 | 0.83 | MME (0.47) | RENMMP1FCER2MMEERAP2 | |
| SCHEMBL9556647 | 0.80 | FCER2 (0.67) | MMP1FCER2MMEERAP2ERAP1 | |
| SCHEMBL7301756 | 0.78 | LMNA (0.56) | CTSSMMP8 | |
| SCHEMBL8909332 | 0.78 | LMNA (0.56) | CTSSMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |