Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338484 | 0.97 | REN (0.38) | RENHSD17B10CTSSCHRM1OPRL1 | |
| SCHEMBL7331323 | 0.91 | KMT2A (0.41) | RENCTSSOPRL1F10LTA4H | |
| SCHEMBL7330457 | 0.91 | REN (0.39) | RENCTSSOPRL1CYP3A4 | |
| SCHEMBL7328094 | 0.89 | CTSS (0.32) | RENCTSS | |
| SCHEMBL7332394 | 0.86 | RORC (0.32) | RENCTSS | |
| SCHEMBL7331419 | 0.84 | AVPR1A (0.39) | HSD17B10AVPR1APLGTSHR | |
| SCHEMBL7330956 | 0.84 | REN (0.46) | RENHSD17B10CTSSCHRM1OPRL1 | |
| SCHEMBL7331301 | 0.83 | REN (0.45) | RENHSD17B10CTSSCHRM1OPRL1 | |
| SCHEMBL7332856 | 0.82 | REN (0.38) | RENHSD17B10CTSSCHRM1OPRL1 | |
| SCHEMBL7331684 | 0.81 | AVPR1A (0.37) | RENHSD17B10CHRM1AVPR1APLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |