Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324893 | 0.83 | MTNR1A (0.65) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL7326549 | 0.81 | MTNR1A (0.62) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| Hydrochloric Acid SCHEMBL7330037 | 0.80 | DRD2 (0.59) | DRD2DRD3DRD4 | |
| SCHEMBL7335952 | 0.80 | MTNR1A (0.60) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL7333316 | 0.77 | MTNR1A (0.67) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL827706 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL2597383 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL4112887 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL2597485 | 0.75 | MTNR1A (0.84) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL30089783 | 0.75 | MTNR1A (0.84) | MTNR1AMTNR1BCYP1A2ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |