Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 4/20 | 0.34 |
| ▸ | CSF1R | P07333 | 4/20 | 0.34 |
| ▸ | LYN | P07948 | 4/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.34 |
| ▸ | SIK1 | P57059 | 4/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 4/20 | 0.34 |
| ▸ | SIK3 | Q9Y2K2 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730668 | 0.83 | KDM4E (0.39) | LRRK2PIM1ABL1SIK1SIK2 | |
| SCHEMBL730763 | 0.79 | KIT (0.37) | PIK3CDPIK3CAPIK3CGSYK | |
| SCHEMBL731170 | 0.78 | PLAU (0.39) | LRRK2PIK3CDPIK3CAPIK3CGABL1 | |
| SCHEMBL732896 | 0.77 | RIPK1 (0.38) | LRRK2KDM5BKCNH2MAP3K12KDM5A | |
| SCHEMBL730889 | 0.72 | GRM5 (0.39) | KCNH2MAPK1 | |
| SCHEMBL732594 | 0.70 | TTK (0.37) | LRRK2KCNH2PIM1 | |
| SCHEMBL733080 | 0.69 | LMNA (0.33) | — | |
| SCHEMBL731429 | 0.68 | ALDH1A1 (0.42) | — | |
| SCHEMBL1032787 | 0.67 | PIK3CD (0.44) | LRRK2PIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL3607256 | 0.66 | L3MBTL1 (0.42) | LRRK2PIK3CDPIK3CAPIK3CGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | LRRK2 2283/4885PIK3CD 3833/4885PIK3CA 2745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.