Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332240 | 1.00 | ACE (0.42) | ACEALDH1A1HPGDMAPK1LMNA | |
| SCHEMBL7330364 | 0.85 | ACE (0.55) | ACE | |
| SCHEMBL7330368 | 0.85 | ACE (0.55) | ACE | |
| SCHEMBL7326265 | 0.83 | TPSAB1 (0.42) | ACE | |
| SCHEMBL7322584 | 0.82 | ACE (0.55) | ACE | |
| SCHEMBL7322575 | 0.82 | ACE (0.55) | ACE | |
| SCHEMBL7431619 | 0.79 | ALDH1A1 (0.37) | ALDH1A1HPGDMAPK1LMNAMAPT | |
| SCHEMBL11109004 | 0.79 | ALDH1A1 (0.37) | ALDH1A1HPGDMAPK1LMNAMAPT | |
| SCHEMBL4445452 | 0.79 | HPGD (0.54) | ALDH1A1HPGDMAPK1 | |
| SCHEMBL7324994 | 0.78 | ACE (0.47) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4598071-A | ANGIOTENSIN INHIBITORS/ | E. R. SQUIBB & SONS, INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4567167-A | INHIBITOR OF ANGIOTENDIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | disclosed |