Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334082 | 0.85 | GABRA1 (0.37) | GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL7337972 | 0.78 | GABRA1 (0.38) | GABRA1GABRA5GABRG2GABRB3HPGD | |
| SCHEMBL8569428 | 0.78 | CNR2 (0.39) | AVPR1BCNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL7328800 | 0.73 | GABRA1 (0.39) | GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL7330862 | 0.73 | GABRA1 (0.51) | GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL14463533 | 0.71 | LMNA (0.47) | GABRA1GABRA5MEN1KMT2AALDH1A1 | |
| SCHEMBL7291196 | 0.70 | PTPN2 (0.41) | GABRA1GABRA5GABRG2GABRB3KMT2A | |
| SCHEMBL9599814 | 0.68 | GABRA1 (0.47) | GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL7335649 | 0.67 | GABRA1 (0.39) | GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL7335647 | 0.67 | GABRA1 (0.39) | GABRA1GABRA5GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833638-B1 | USE OF IMIDAZO 1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS | UPJOHN CO (US) | 2001-11-21 | — | — | EP | claimed |
| US-5935970-A | Use of imidazo 1,5-a!quinolones as neuroprotective agents | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-10 | — | — | US | claimed |
| US-RE35840-E | Imidazo 1,5-a!quinolines for treatment of anxiety and sleep disorders | PHARMACIA & UPJOHN COMPANY (US) | 1998-07-07 | — | — | US | claimed |
| EP-0833638-A1 | USE OF IMIDAZO 1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-08 | — | — | EP | claimed |
| US-5594140-A | Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | claimed |
| WO-1997000074-A1 | USE OF IMIDAZO[1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-03 | — | — | WO | claimed |
| EP-0729469-A1 | IMIDAZO [1,5-a]QUINOLINES FOR TREATMENT OF ANXIETY AND SLEEP DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-09-04 | — | — | EP | claimed |
| WO-1995014020-A1 | IMIDAZO[1,5-a]QUINOLINES FOR TREATMENT OF ANXIETY AND SLEEP DISORDERS | THE UPJOHN COMPANY (US) | 1995-05-26 | — | — | WO | claimed |