Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450319 | 0.94 | ADRB2 (0.51) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL7333081 | 0.88 | ADRB2 (0.54) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL9131862 | 0.86 | ADRB2 (0.53) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL9130967 | 0.86 | ADRB2 (0.53) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL6451228 | 0.86 | HTR1A (0.72) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL9450011 | 0.86 | ADRB3 (0.57) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL9450097 | 0.85 | ABCB1 (0.62) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL9450087 | 0.85 | CYP2D6 (0.51) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL9518687 | 0.85 | MEN1 (0.64) | ADRB2CYP1A2ADRB1MEN1KMT2A | |
| SCHEMBL10563835 | 0.84 | ADRB2 (0.51) | ADRB2CYP1A2ADRB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395528-B1 | 4-Phenylmethyl-1H-indole derivatives, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1995-07-05 | — | — | EP | claimed |
| US-5086070-A | 4-BENZYL-1H-INDOLES AND ANTI-ARRTHYMIC USE THEREOF | ROUSSEL UCLAF (FR) | 1992-02-04 | — | — | US | claimed |
| US-5182282-A | Antiarrhythmia agents | ROUSSEL UCLAF (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5086070-A | 4-BENZYL-1H-INDOLES AND ANTI-ARRTHYMIC USE THEREOF | ROUSSEL UCLAF (FR) | 1992-02-04 | — | — | US | disclosed |