Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312519 | 0.89 | TTR (0.48) | ALDH1A1GLAKMT2ATTRAHR | |
| SCHEMBL7317925 | 0.78 | TTR (0.39) | ALDH1A1KMT2ATTRAHRNPC1 | |
| SCHEMBL7371970 | 0.77 | NPC1 (0.43) | ALDH1A1KMT2ATTRAHRNPC1 | |
| SCHEMBL7317931 | 0.76 | KDM4E (0.35) | ALDH1A1GLAKMT2ATTRAHR | |
| SCHEMBL23690159 | 0.76 | AHR (0.50) | ALDH1A1KMT2ATTRAHRNPC1 | |
| SCHEMBL11888493 | 0.73 | ALDH1A1 (0.50) | ALDH1A1GLAKMT2ANPC1RAB9A | |
| SCHEMBL20793973 | 0.71 | ALOX5 (0.45) | ALDH1A1GLAKMT2AATMKDM4E | |
| SCHEMBL30476189 | 0.71 | ALDH1A1 (0.76) | ALDH1A1GLAKMT2AATMNPC1 | |
| SCHEMBL2012858 | 0.71 | ALDH1A1 (0.76) | ALDH1A1GLAKMT2AATMNPC1 | |
| SCHEMBL30641305 | 0.70 | ALDH1A1 (0.43) | ALDH1A1GLAKMT2AAHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664806-A1 | HETEROCYCLIC CONDENSED BENZOIC ACID DERIVATIVES AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | claimed |
| WO-1994008995-A1 | HETEROCYCLIC CONDENSED BENZOIC ACID DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | claimed |