SCHEMBL7334432

SCHEMBL7334432

CCc1c(C(O)[C@H](CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc2ccccc2)c1=O

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CTSK P43235 13/20 0.59
PSMB1 P20618 1/20 0.57
CTSL P07711 5/20 0.56
CTSS P25774 3/20 0.56
CTSB P07858 3/20 0.56
CAPN1 P07384 1/20 0.52
CAPN2 P17655 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7334420 1.00 CTSK (0.59) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL7344647 0.84 CTSK (0.64) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL7344663 0.84 CTSK (0.64) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL7340230 0.81 CTSK (0.56) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL6828336 0.79 CTSK (0.66) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL6444976 0.79 CTSK (0.72) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL8972715 0.79 CTSK (0.69) CTSKPSMB1CTSLCTSSCTSB
SCHEMBL7337277 0.78 CTSK (0.59) CTSKCTSLCTSSCTSB
SCHEMBL7337267 0.78 CTSK (0.59) CTSKCTSLCTSSCTSB
SCHEMBL7345360 0.78 CTSK (0.61) CTSKPSMB1CTSLCTSSCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0520427-B1 Cyclopropenone derivatives MITSUBISHI CHEM IND (JP) 1994-12-14 EP disclosed
US-5328909-A Protease inhibitors MITSUBISHI KASEI CORPORATION (JP) 1994-07-12 US disclosed
EP-0520427-A1 Cyclopropenone derivatives Mitsubishi Chemical Corporation (JP) 1992-12-30 EP disclosed