Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.72 |
| ▸ | CTSL | P07711 | 7/20 | 0.67 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.66 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.65 |
| ▸ | CTSS | P25774 | 3/20 | 0.65 |
| ▸ | CTSB | P07858 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8951282 | 0.91 | CAPN1 (0.66) | CTSKCTSLCAPN1PSMB1CTSS | |
| SCHEMBL7270838 | 0.90 | PSMB1 (0.70) | CTSKCTSLCAPN1PSMB1CTSS | |
| SCHEMBL6449605 | 0.89 | TACR1 (0.69) | CTSKCTSLCTSSCTSB | |
| SCHEMBL7345360 | 0.87 | CTSK (0.61) | CTSKCTSLCAPN1PSMB1CTSS | |
| SCHEMBL7345352 | 0.87 | CTSK (0.61) | CTSKCTSLCAPN1PSMB1CTSS | |
| SCHEMBL6559243 | 0.86 | CTSK (0.62) | CTSKCTSLCAPN1PSMB1CTSS | |
| SCHEMBL7327426 | 0.86 | CAPN1 (0.78) | CTSKCTSLCAPN1CTSSCTSB | |
| SCHEMBL9828791 | 0.86 | CAPN1 (0.78) | CTSKCTSLCAPN1CTSSCTSB | |
| SCHEMBL27809377 | 0.86 | CAPN1 (0.78) | CTSKCTSLCAPN1CTSSCTSB | |
| SCHEMBL6446525 | 0.85 | CTSD (0.60) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |