Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.53 |
| ▸ | RAB9A | P51151 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 9/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.53 |
| ▸ | RELA | Q04206 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328447 | 0.91 | MEN1 (0.50) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL7333786 | 0.90 | MEN1 (0.50) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL7331115 | 0.88 | ALOX5 (0.51) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL7329378 | 0.88 | HTR2A (0.59) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL12297264 | 0.72 | MEN1 (0.95) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL1822120 | 0.71 | MEN1 (1.00) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL29276782 | 0.71 | MEN1 (1.00) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL7328556 | 0.70 | MEN1 (0.47) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL183115 | 0.69 | HTR2A (0.62) | NFKB1RECQLLMNACYP1A2 | |
| SCHEMBL9380985 | 0.68 | MEN1 (0.80) | KMT2ARAB9AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405848-A | Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-04-11 | — | — | US | claimed |