Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328447 | 0.74 | MEN1 (0.50) | MEN1KMT2ARAB9ANPC1SENP8 | |
| Water SCHEMBL9658350 | 0.74 | P2RX7 (0.53) | CYP2C19MAPTLMNAGRM5CREBBP | |
| SCHEMBL7333786 | 0.72 | MEN1 (0.50) | MEN1KMT2ARAB9ANPC1SENP8 | |
| SCHEMBL7331115 | 0.70 | ALOX5 (0.51) | MEN1KMT2ARAB9ANPC1SENP8 | |
| SCHEMBL7329378 | 0.70 | HTR2A (0.59) | MEN1KMT2ARAB9ANPC1SENP8 | |
| SCHEMBL7334714 | 0.70 | KMT2A (0.53) | MEN1KMT2ARAB9ANPC1SENP8 | |
| SCHEMBL9659999 | 0.69 | KCNK3 (0.46) | CREBBP | |
| SCHEMBL9660193 | 0.69 | MAPK1 (0.53) | CREBBP | |
| SCHEMBL7334668 | 0.67 | PDGFRB (0.56) | MEN1KMT2ARAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL9659841 | 0.67 | BRD4 (0.53) | CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405848-A | Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-04-11 | — | — | US | disclosed |