Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.46 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330676 | 0.90 | LTA4H (0.43) | — | |
| SCHEMBL7340387 | 0.89 | REN (0.53) | REN | |
| SCHEMBL7338208 | 0.89 | — | — | |
| SCHEMBL7335017 | 0.86 | REN (0.42) | REN | |
| SCHEMBL7339453 | 0.86 | KMT2A (0.42) | — | |
| SCHEMBL7331751 | 0.86 | REN (0.54) | REN | |
| SCHEMBL7329495 | 0.84 | LTA4H (0.48) | — | |
| SCHEMBL7329619 | 0.76 | LTA4H (0.45) | — | |
| SCHEMBL7336138 | 0.75 | REN (0.51) | REN | |
| SCHEMBL11225559 | 0.75 | LTA4H (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |