Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.51 |
| ▸ | FCER2 | P06734 | 5/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.47 |
| ▸ | CTSE | P14091 | 1/20 | 0.47 |
| ▸ | PGC | P20142 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338182 | 0.96 | REN (0.51) | RENFCER2MMP1CTSDPGA5 | |
| SCHEMBL7331287 | 0.89 | REN (0.63) | RENCTSDPGA5CTSEPGC | |
| SCHEMBL7331751 | 0.89 | REN (0.54) | RENFCER2MMP1CTSDPGA5 | |
| SCHEMBL7333230 | 0.87 | REN (0.49) | RENFCER2MMP1CTSDPGA5 | |
| SCHEMBL7330676 | 0.85 | LTA4H (0.43) | — | |
| SCHEMBL7329490 | 0.83 | REN (0.54) | RENFCER2MMP1 | |
| SCHEMBL7338835 | 0.83 | REN (0.46) | RENFCER2MMP1CTSDPGA5 | |
| SCHEMBL7335017 | 0.82 | REN (0.42) | REN | |
| SCHEMBL7332174 | 0.80 | MMP2 (0.51) | MMP1 | |
| SCHEMBL7332179 | 0.80 | MMP2 (0.51) | MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |