Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.51 |
| ▸ | MMP9 | P14780 | 5/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332179 | 1.00 | MMP2 (0.51) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL7338097 | 0.87 | ITGB3 (0.48) | MMP2MMP9POLBHSD17B10CHRM1 | |
| SCHEMBL7338091 | 0.87 | ITGB3 (0.48) | MMP2MMP9POLBHSD17B10CHRM1 | |
| SCHEMBL8683934 | 0.86 | ALDH1A1 (0.58) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL7385524 | 0.84 | MEN1 (0.61) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL7317104 | 0.84 | MEN1 (0.61) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL9437655 | 0.82 | HSD17B10 (0.40) | ALDH1A1HSD17B10KMT2ACHRM1MEN1 | |
| SCHEMBL9437573 | 0.82 | ALDH1A1 (0.39) | ALDH1A1HSD17B10LMNATP53KMT2A | |
| SCHEMBL7350808 | 0.81 | YAP1 (0.54) | ALDH1A1MAPT | |
| SCHEMBL9437646 | 0.81 | HSD17B10 (0.40) | MMP2MMP9ADAMTS4HSD17B10CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |