Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334771 | 0.90 | KDM4E (0.42) | KCNH2SLC6A9ALDH1A1L3MBTL1LPAR1 | |
| SCHEMBL7367814 | 0.89 | SLC6A9 (0.41) | KCNH2SLC6A9TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL7333544 | 0.89 | KCNH2 (0.38) | THRBKCNH2SLC6A9POLBTP53 | |
| SCHEMBL7336180 | 0.86 | KCNH2 (0.45) | KCNH2POLBTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL7343912 | 0.84 | L3MBTL1 (0.44) | ALDH1A1MAPK1HSD17B10MAPTL3MBTL1 | |
| SCHEMBL7333092 | 0.80 | TRPM8 (0.41) | POLBTRPM8TP53 | |
| SCHEMBL7333407 | 0.79 | KDM4E (0.41) | ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7335668 | 0.79 | DRD2 (0.45) | THRBKCNH2SLC6A9ALDH1A1 | |
| SCHEMBL8346553 | 0.78 | DRD2 (0.44) | THRBKCNH2SLC6A9ALDH1A1L3MBTL1 | |
| SCHEMBL7335763 | 0.76 | KCNH2 (0.43) | KCNH2SLC6A9POLBTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103744-A | ADMINISTERING TO THE PATIENT A DOPAMINE AUTORECEPTOR AGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON,S DISEASE, TOURETTE,S SYNDROM, ALCOHOLISM AND DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0964854-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0964853-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| US-5972958-A | 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998035946-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035947-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |