Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.57 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 10/20 | 0.60 |
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8979317 | 1.00 | DRD2 (0.60) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL9295674 | 0.99 | DRD2 (0.61) | DRD2DRD3DRD4ADRA1DADRA1A | |
| Bromide SCHEMBL7336392 | 0.92 | DRD2 (0.69) | DRD2DRD3DRD4ADRA1DADRA1A | |
| Bromide SCHEMBL7336396 | 0.92 | DRD2 (0.69) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL7424159 | 0.91 | DRD2 (0.71) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL7424155 | 0.91 | DRD2 (0.71) | DRD2DRD3DRD4ADRA1DADRA1A | |
| Bromide SCHEMBL7271594 | 0.91 | ADRA1D (0.63) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL7279815 | 0.89 | ADRA1D (0.64) | DRD2DRD3DRD4ADRA1DADRA1A | |
| Bromide SCHEMBL11042776 | 0.79 | DRD2 (0.66) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7272021 | 0.79 | ADRA1A (0.62) | DRD2DRD3DRD4ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585440-B1 | 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON SPA (IT) | 1996-05-08 | — | — | EP | disclosed |
| US-5451608-A | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovasular system, processes for their preparation and pharmaceutical compositions containing them | ZAMBON GROUP S.P.A. (IT) | 1995-09-19 | — | — | US | disclosed |
| US-5407956-A | Hypotensive agents, kidney disorders | ZAMBON GROUP S.P.A. (IT) | 1995-04-18 | — | — | US | disclosed |
| WO-1993019036-A1 | 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON GROUP S.P.A. (IT) | 1993-09-30 | — | — | WO | disclosed |