Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338490 | 0.87 | AURKB (0.44) | AURKBINCENPPDE3BPDE3AAURKA | |
| SCHEMBL7340801 | 0.85 | AURKB (0.43) | AURKBINCENPPDE3BPDE3AAURKA | |
| SCHEMBL7346248 | 0.81 | SIRT3 (0.41) | KDM4EHTTDAOCDC7ROCK2 | |
| SCHEMBL7339359 | 0.79 | KDM4E (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7347685 | 0.78 | PDE3B (0.45) | AURKBINCENPPDE3BPDE3AAURKA | |
| SCHEMBL11067511 | 0.76 | PDE3B (0.43) | AURKBINCENPPDE3BPDE3AROCK2 | |
| SCHEMBL11121162 | 0.75 | AURKB (0.42) | AURKBINCENPPDE3BPDE3AAURKA | |
| SCHEMBL11092286 | 0.72 | AURKB (0.38) | AURKBINCENPPDE3BPDE3AAURKA | |
| SCHEMBL14452876 | 0.69 | SIGMAR1 (0.48) | PDE3BPDE3AMEN1ALDH1A1LMNA | |
| SCHEMBL29699898 | 0.69 | SIGMAR1 (0.48) | PDE3BPDE3AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |