Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 4/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328414 | 0.80 | RXFP1 (0.50) | ADORA3ADORA2AADORA1PDE5APDE10A | |
| SCHEMBL7332950 | 0.78 | ADORA2A (0.38) | ADORA3ADORA2AADORA1PDE5APDE10A | |
| SCHEMBL7330632 | 0.78 | PDE1A (0.44) | PDE10APDE4BMAPTNPSR1MAT2A | |
| SCHEMBL7328438 | 0.78 | PIM1 (0.43) | ADORA3ADORA2AADORA1PDE5APDE10A | |
| SCHEMBL7330374 | 0.77 | KMT2A (0.47) | — | |
| SCHEMBL7332532 | 0.76 | MAOA (0.50) | ADORA3ADORA2AADORA1PDE10ANR3C1 | |
| SCHEMBL7331699 | 0.75 | PDE5A (0.51) | PDE5APDE4BMAT2A | |
| SCHEMBL7330944 | 0.74 | LMNA (0.44) | ADORA3ADORA2AADORA1PDE5APDE10A | |
| SCHEMBL7338751 | 0.74 | PDE5A (0.70) | PDE5APDE4BMAT2ABCDIN3DCYP1A2 | |
| SCHEMBL7332575 | 0.73 | NPC1 (0.48) | NR3C1MAPTNPSR1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942520-A | Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines | CELL PATHWAYS, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |