Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328414 | 0.82 | RXFP1 (0.50) | NR3C1ADORA1ADORA3ADORA2APGR | |
| SCHEMBL7330632 | 0.80 | PDE1A (0.44) | PDE4BPDE10AMAPTNPSR1 | |
| SCHEMBL7332532 | 0.78 | MAOA (0.50) | NR3C1ADORA1ADORA3ADORA2APDE10A | |
| SCHEMBL7332950 | 0.78 | ADORA2A (0.38) | NR3C1ADORA1ADORA3ADORA2APGR | |
| SCHEMBL7337974 | 0.78 | ADORA3 (0.36) | NR3C1ADORA1ADORA3ADORA2APGR | |
| SCHEMBL7330374 | 0.77 | KMT2A (0.47) | — | |
| SCHEMBL7332575 | 0.75 | NPC1 (0.48) | NR3C1MAPTNPSR1 | |
| SCHEMBL7428137 | 0.75 | NR3C1 (0.46) | NR3C1ADORA1ADORA3ADORA2APGR | |
| SCHEMBL7330944 | 0.74 | LMNA (0.44) | NR3C1ADORA1ADORA3ADORA2APGR | |
| SCHEMBL7338059 | 0.74 | PDE10A (0.56) | PDE5APDE10AMAPTTSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942520-A | Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines | CELL PATHWAYS, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |