Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAT2A | P31153 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333313 | 0.77 | PDE5A (0.49) | NPC1LMNASMN1; SMN2RAB9AMAT2A | |
| SCHEMBL7328414 | 0.77 | RXFP1 (0.50) | LMNAMAPTNR3C1KDM4ENPSR1 | |
| SCHEMBL7338172 | 0.75 | HCAR3 (0.46) | NPC1SMN1; SMN2RAB9AGAAMAPT | |
| SCHEMBL7332950 | 0.75 | ADORA2A (0.38) | MAT2ANR3C1 | |
| SCHEMBL7330632 | 0.75 | PDE1A (0.44) | SMN1; SMN2GAAMAT2AMAPTKDM4E | |
| SCHEMBL7328438 | 0.75 | PIM1 (0.43) | MAPTNR3C1NPSR1 | |
| SCHEMBL7330374 | 0.74 | KMT2A (0.47) | LMNAMEN1KMT2A | |
| SCHEMBL7337974 | 0.73 | ADORA3 (0.36) | MAT2AMAPTNR3C1NPSR1 | |
| SCHEMBL7330944 | 0.72 | LMNA (0.44) | LMNASMN1; SMN2NR3C1MEN1KMT2A | |
| SCHEMBL7428137 | 0.70 | NR3C1 (0.46) | LMNASMN1; SMN2RAB9AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942520-A | Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines | CELL PATHWAYS, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |