SCHEMBL7337992

SCHEMBL7337992

C=CC(c1ccc(OCCN2CCOCC2)cc1)C(CCCC)C(N)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.51
MAPK1 P28482 2/20 0.51
CYP1A2 P05177 1/20 0.51
CHRM2 P08172 1/20 0.51
CHRM1 P11229 1/20 0.51
HTR2A P28223 1/20 0.51
SCN1A P35498 1/20 0.51
HTR2B P41595 1/20 0.51
KCNH2 Q12809 1/20 0.51
SCN2A Q99250 1/20 0.51
SIGMAR1 Q99720 1/20 0.51
SCN3A Q9NY46 1/20 0.51
HRH3 Q9Y5N1 1/20 0.51
LMNA P02545 4/20 0.50
SMN1; SMN2 Q16637 4/20 0.50
THRB P10828 3/20 0.50
KMT2A Q03164 3/20 0.50
MAPT P10636 3/20 0.50
USP2 O75604 2/20 0.50
GAA P10253 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7331713 0.77 ALDH1A1 (0.56) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL10376 0.76 SMN1; SMN2 (0.58) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL7338549 0.76 ALDH1A1 (0.51) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL7338536 0.76 ALDH1A1 (0.51) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL7338002 0.76 THRB (0.53) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL7335011 0.76 ALDH1A1 (0.51) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL7335004 0.76 ALDH1A1 (0.51) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL29508217 0.75 ALDH1A1 (0.88) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL10625 0.73 HRH3 (0.61) ALDH1A1MAPK1CYP1A2CHRM2CHRM1
SCHEMBL863648 0.73 ALDH1A1 (0.60) ALDH1A1MAPK1CYP1A2CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0434365-A2 HIV protease inhibitors useful for the treatment of aids MERCK & CO. INC. (US) 1991-06-26 EP disclosed