Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338091 | 1.00 | ITGB3 (0.48) | ITGB3ITGA2BCA12CA7CA9 | |
| SCHEMBL7332174 | 0.87 | MMP2 (0.51) | HSD17B10POLBCHRM1MMP2MMP9 | |
| SCHEMBL7332179 | 0.87 | MMP2 (0.51) | HSD17B10POLBCHRM1MMP2MMP9 | |
| SCHEMBL7273216 | 0.79 | POLB (0.64) | ITGB3ITGA2BTACR1HSD17B10POLB | |
| SCHEMBL9819677 | 0.79 | POLB (0.55) | CA12CA7CA9CA14CA2 | |
| SCHEMBL20335114 | 0.79 | POLB (0.55) | CA12CA7CA9CA14CA2 | |
| SCHEMBL9113795 | 0.78 | CTSK (0.46) | POLBCTSLCTSBCTSSCTSK | |
| SCHEMBL9437621 | 0.78 | HSD17B10 (0.39) | ITGB3ITGA2BHSD17B10CHRM1AVPR1B | |
| SCHEMBL9437655 | 0.77 | HSD17B10 (0.40) | HSD17B10CHRM1AVPR1BCTSLCTSB | |
| SCHEMBL18811597 | 0.77 | HSD17B10 (0.46) | ITGB3ITGA2BHSD17B10POLBCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |