Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP1 | Q9P0U3 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338973 | 1.00 | SENP1 (0.46) | SENP1PPARGSIRT2ALDH1A1L3MBTL1 | |
| SCHEMBL7383610 | 0.92 | KCNK3 (0.48) | SENP1PPARGSIRT2ALDH1A1L3MBTL1 | |
| SCHEMBL7383607 | 0.92 | KCNK3 (0.48) | SENP1PPARGSIRT2ALDH1A1L3MBTL1 | |
| SCHEMBL7345956 | 0.91 | KCNK3 (0.45) | SENP1L3MBTL1LMNAKCNK3KCNK9 | |
| SCHEMBL7346968 | 0.91 | KCNK3 (0.45) | SENP1L3MBTL1LMNAKCNK3KCNK9 | |
| SCHEMBL7350687 | 0.90 | KCNK3 (0.44) | SENP1ALDH1A1L3MBTL1LMNAKCNK3 | |
| SCHEMBL7350667 | 0.90 | KCNK3 (0.44) | SENP1ALDH1A1L3MBTL1LMNAKCNK3 | |
| SCHEMBL7453653 | 0.81 | PPARG (0.54) | SENP1PPARGALDH1A1MAPK1LMNA | |
| SCHEMBL7372795 | 0.81 | PPARG (0.54) | SENP1PPARGALDH1A1MAPK1LMNA | |
| SCHEMBL7338985 | 0.81 | ITGB3 (0.47) | SENP1ALDH1A1L3MBTL1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |