Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350687 | 1.00 | KCNK3 (0.44) | KCNK3KCNK9ITGB1ITGA5HTT | |
| SCHEMBL7345956 | 0.92 | KCNK3 (0.45) | KCNK3KCNK9ITGB1ITGA5HTT | |
| SCHEMBL7346968 | 0.92 | KCNK3 (0.45) | KCNK3KCNK9ITGB1ITGA5HTT | |
| SCHEMBL7338973 | 0.90 | SENP1 (0.46) | KCNK3KCNK9ITGB1ITGA5HTT | |
| SCHEMBL7338982 | 0.90 | SENP1 (0.46) | KCNK3KCNK9ITGB1ITGA5HTT | |
| SCHEMBL7383610 | 0.81 | KCNK3 (0.48) | KCNK3KCNK9L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL7383607 | 0.81 | KCNK3 (0.48) | KCNK3KCNK9L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL6777356 | 0.80 | ITGB1 (0.42) | ITGB1ITGA5HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL7350678 | 0.79 | ITGB1 (0.53) | ITGB1ITGA5LMNAGPR139 | |
| SCHEMBL6779632 | 0.78 | GPR139 (0.48) | ITGB1ITGA5GPR139MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |