Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.58 |
| ▸ | CRHBP | P24387 | 3/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345303 | 0.83 | ALDH1A1 (1.00) | ALDH1A1NPC1RAB9ANPSR1KMT2A | |
| SCHEMBL7945716 | 0.82 | ALDH1A1 (0.53) | ALDH1A1NPC1RAB9ANPSR1KMT2A | |
| SCHEMBL11612271 | 0.82 | ALDH1A1 (0.62) | ALDH1A1NPC1RAB9ANPSR1KMT2A | |
| SCHEMBL21247872 | 0.82 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9ANPSR1KMT2A | |
| SCHEMBL21800147 | 0.81 | CRHBP (0.55) | ALDH1A1KMT2ACRHBPCRHR2MEN1 | |
| SCHEMBL21800136 | 0.79 | CRHBP (0.52) | ALDH1A1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL11291473 | 0.79 | ALDH1A1 (0.62) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL21800130 | 0.78 | CRHBP (0.51) | ALDH1A1KMT2APOLBCRHBPCRHR2 | |
| SCHEMBL1232308 | 0.78 | MAPT (0.49) | ALDH1A1NPC1RAB9ANPSR1KMT2A | |
| SCHEMBL9507468 | 0.77 | CRHBP (0.64) | ALDH1A1NPSR1KMT2AHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |