Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.42 |
| ▸ | EDNRB | P24530 | 3/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830902 | 0.90 | ALDH1A1 (0.36) | EDNRAEDNRBHCRTR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7336214 | 0.88 | EDNRA (0.42) | EDNRAEDNRBHCRTR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7339542 | 0.88 | EDNRA (0.42) | EDNRAEDNRBSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7071144 | 0.84 | EDNRA (0.50) | EDNRAEDNRBHCRTR2KMT2A | |
| SCHEMBL7067173 | 0.80 | EDNRA (0.45) | EDNRAEDNRBHCRTR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7342779 | 0.77 | HCRTR2 (0.52) | EDNRAEDNRBHCRTR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7336270 | 0.73 | HCRTR2 (0.41) | EDNRAEDNRBHCRTR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7829178 | 0.72 | EDNRA (0.44) | EDNRAEDNRBALDH1A1PKMKDM4E | |
| SCHEMBL7334893 | 0.72 | EDNRA (0.51) | EDNRAEDNRBALDH1A1KDM4E | |
| SCHEMBL7345193 | 0.72 | EDNRA (0.51) | EDNRAEDNRBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |