Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 4/20 | 0.34 |
| ▸ | EDNRB | P24530 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339366 | 0.90 | EDNRA (0.42) | ALDH1A1SMN1; SMN2KDM4ENPC1PKM | |
| SCHEMBL7339542 | 0.87 | EDNRA (0.42) | ALDH1A1SMN1; SMN2KDM4ENPC1PKM | |
| SCHEMBL7336214 | 0.87 | EDNRA (0.42) | ALDH1A1SMN1; SMN2KDM4ENPC1PKM | |
| SCHEMBL7829178 | 0.82 | EDNRA (0.44) | ALDH1A1MAPK1CMA1KDM4EPKM | |
| SCHEMBL7071144 | 0.72 | EDNRA (0.50) | EDNRAEDNRBKMT2AHCRTR2 | |
| SCHEMBL7069874 | 0.72 | EDNRA (0.56) | ALDH1A1EDNRAEDNRBHCRTR2 | |
| SCHEMBL7068083 | 0.69 | EDNRA (0.42) | ALDH1A1MAPK1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7345193 | 0.69 | EDNRA (0.51) | ALDH1A1KDM4EEDNRAEDNRB | |
| SCHEMBL7334893 | 0.69 | EDNRA (0.51) | ALDH1A1KDM4EEDNRAEDNRB | |
| SCHEMBL7067173 | 0.68 | EDNRA (0.45) | ALDH1A1SMN1; SMN2NPC1EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |