⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423937 | 0.74 | — | — | |
| SCHEMBL8885972 | 0.71 | LMNA (0.45) | — | |
| SCHEMBL424438 | 0.70 | HPGD (0.43) | — | |
| SCHEMBL423679 | 0.69 | — | — | |
| SCHEMBL13263069 | 0.69 | PARP14 (0.30) | — | |
| SCHEMBL6170484 | 0.69 | ADH1B (0.36) | — | |
| SCHEMBL425469 | 0.69 | ALDH1A1 (0.35) | — | |
| SCHEMBL8637402 | 0.67 | FAAH (0.46) | — | |
| SCHEMBL7688952 | 0.67 | ADH1B (0.30) | — | |
| SCHEMBL1751775 | 0.67 | FAAH (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020143011-A1 | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED | 2002-10-03 | — | — | US | disclosed |
| US-6077854-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-20 | — | — | US | disclosed |
| EP-0944599-A1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-29 | — | — | EP | disclosed |
| US-5891896-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-04-06 | — | — | US | disclosed |
| US-5859034-A | Tri-substituted phenyl compounds which have useful pharmaceutical activity | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| US-5849770-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1998-12-15 | — | — | US | disclosed |
| EP-0874824-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| EP-0874823-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| US-5798373-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-08-25 | — | — | US | disclosed |
| US-5786354-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-28 | — | — | US | disclosed |
| WO-1998028276-A1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |
| WO-1997023460-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-07-03 | — | — | WO | disclosed |
| WO-1997023461-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-07-03 | — | — | WO | disclosed |
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |