Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | CMA1 | P23946 | 10/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6412055 | 0.87 | ACE (0.66) | F2PRSS1ACECMA1KLK5 | |
| SCHEMBL6412059 | 0.87 | ACE (0.66) | F2PRSS1ACECMA1KLK5 | |
| SCHEMBL7087290 | 0.87 | ACE (0.66) | F2PRSS1ACECMA1KLK5 | |
| SCHEMBL7343554 | 0.86 | ACE (0.51) | F2PRSS1ACE | |
| SCHEMBL7339527 | 0.83 | FKBP1A (0.51) | F2PRSS1ACECMA1KLK5 | |
| SCHEMBL7339539 | 0.83 | FKBP1A (0.51) | F2PRSS1ACECMA1KLK5 | |
| SCHEMBL7319098 | 0.83 | ACE (0.51) | F2PRSS1ACECMA1KLK5 | |
| SCHEMBL7337615 | 0.82 | ITGB3 (0.58) | F2PRSS1ACECMA1 | |
| SCHEMBL15384069 | 0.82 | KLK5 (0.52) | F2PRSS1ACEKLK5 | |
| SCHEMBL7337624 | 0.82 | CMA1 (0.45) | F2PRSS1ACECMA1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |